The aim of the present study was to produce controlled release Microsponge gels containing voriconazole with varying proportions of Eudragit RS100 and Eudragit L100 as polymers were successfully formulated using quasi-emulsion solvent diffusion method and evaluated. The scanning electron microscopy showed that they were spherical in shape and porous in nature. Physical characterization showed that formulations MSIV and MLIV showed a better loading efficiency. The formulations showed good viscosity and drug release characteristics. The antimicrobial studies showed zone of inhibition with 18.5 mm and19.0 mm for microsponge formulation gel MSIV and MLIV respectively when compared Marketed Fluconazole, zone of inhibition of 19.5mm. Fluconazole gel was used as control in our studies. In vivo studies were performed on guinea pigs. Fungal infection was induced on the skin of these animals using candida albicans. The results indicate that voriconazole when formulated as a microsponge system was capable of producing excellent antimicrobial and antifungal effect at par with conventional control gel of fluconazole. Thus voriconazole microsponges can be considered as a promising alternative in the effective treatment of fungal infections in the form of a gel for faster relief in patients suffering for invasive fungal infections
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